{"id":141910,"date":"2024-09-25T18:16:18","date_gmt":"2024-09-25T18:16:18","guid":{"rendered":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/09\/25\/a-study-in-mice-hints-at-a-new-way-to-treat-spinal-cord-injuries\/"},"modified":"2024-09-25T18:16:18","modified_gmt":"2024-09-25T18:16:18","slug":"a-study-in-mice-hints-at-a-new-way-to-treat-spinal-cord-injuries","status":"publish","type":"post","link":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/09\/25\/a-study-in-mice-hints-at-a-new-way-to-treat-spinal-cord-injuries\/","title":{"rendered":"A study in mice hints at a new way to treat spinal cord injuries"},"content":{"rendered":"<div style=\"text-align:center\"><\/div> \r\n<br><div>\n\t\t\t<div class=\"rich-text rich-text--with-sidebar single__rich-text___RmCDp\" data-component=\"video-embed\">\n\t\t\t\t\n\n\n\n\n<p>After a devastating spinal cord injury, mice\u2019s nerve cells balloon up in size. Some of these neurons <a href=\"https:\/\/www.science.org\/doi\/10.1126\/scitranslmed.adn7095?adobe_mc=MCMID%3D67433961507271871491436304606283365162%7CMCORGID%3D242B6472541199F70A4C98A6%2540AdobeOrg%7CTS%3D1727197687\" target=\"_blank\" rel=\"noopener\">stay swollen longer than expected<\/a> and begin to die, a study published September 25 in <em>Science Translational Medicine<\/em> shows. A drug that brought this swelling down improved the mice\u2019s recovery, though it\u2019s not yet known if the approach would work in people.<\/p>\n\n\n\n<p>Until now, the details of neuron swelling in the spinal cord weren\u2019t clear, says Bo Chen, a neuroscientist at the University of Texas Medical Branch at Galveston. \u201cWe didn\u2019t know how long [the cells stay swollen], or if they\u2019re going to die,\u201d he says. \u201cWe were guessing.\u201d<\/p>\n\n\n<aside class=\"sn-conversion rich-text rich-text--with-sidebar\">\n<style><![CDATA[\n.email-conversion {\n  border: 1px solid #ffcccb;\n  color: white;\n  margin-top: 50px;\n  background-image: url(\"\/wp-content\/themes\/sciencenews\/client\/src\/images\/cta-module@2x.jpg\");\n  padding: 20px;\n  clear: both;\n}\n\n]]><\/style>\n\n\n\n                        <style class=\"is-layout-flow 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none;\n}\n\nform.zephr-form-content {\n    opacity: .9;\n}\n\nlabel.zephr-form-checkbox-label {\n    font-size: 1.2rem;\n    font-weight: bolder;\n}\n\n.zephr-form-custom-text > h4 {\n    color: black !important;\n}\n\nbutton.zephr-form-button {\n    background: #d4441f !important;\n    font-weight: bold !important;\n    text-transform: uppercase !important;\n}\n\nlabel.zephr-payment-form-checkbox-label {\n    color: white;\n    font-size: 1.6rem;\n}\n\n.zephr-form-content {\n    background:#2f537f;\n    \n}\n\n.zephr-payment-form-custom-text {\n    margin-top: .2rem;\n}\n\n.zephr-payment-form-checkbox-label {\n    display: flex;\n    align-items: center;\n    font-family: var(--zephr-typography-body-font), var(--zephr-typography-body-fallbackFont);\n    color: white;\n    font-weight: bold;\n}]]><\/style>\n                        \n                        \n<\/aside>\n\n\n<p>Chen and his colleagues devised a way to watch these cells in the aftermath of a spinal cord injury. The approach relied on genetic engineering, transparent spinal cord tissue and machine learning to help analyze cell shapes. It ultimately yielded views of more than 30,000 neurons spread across a 3-millimeter span of spinal cord of each mouse.<\/p>\n\n\n\n<p>Cells called inhibitory neurons, which dampen other cells\u2019 activity, swelled quickly after an injury, peaking at day two and returning to their normal size by day 14, the team found. But excitatory neurons showed a very different pattern. These cells, which ramp up other cells\u2019 activity, ballooned up and stayed swollen longer, some for up to 35 days. More of these kinds of cells died, too.<\/p>\n\n\n\n<p>A drug called bumetanide, which is used to treat edema in people, reduced this cellular swelling and resulting cell death in mice. Mice given the drug after an injury were better able to move their legs than mice not given the drug, the researchers report.<\/p>\n\n\n\n<p>The results point to neuron swelling as an important part of spinal cord injuries. Still, more research needs to be done to understand how this process works in people, and whether bumetanide might help, Chen says.<\/p>\n\n\n\n\t\t\t<\/div> <!-- \/.rich-text -->\n\t\t\t\n<footer class=\"article-footer__wrapper___eChRS article-footer__with-sidebar___9oDuK\">\n\t\t\t<p class=\"article-footer__feedback___sNXjz\">Questions or comments on this article? E-mail us at\u00a0<a href=\"https:\/\/www.sciencenews.org\/article\/mailto:feedback@sciencenews.org\">feedback@sciencenews.org<\/a> | <a href=\"https:\/\/www.sciencenews.org\/permission-republish\">Reprints FAQ<\/a><\/p>\n\t\n\t\n\t\n\t\n\n\n\t\n<div class=\"author-bio__wrapper___ODe-4\">\n\t\t\t<figure class=\"author-bio__figure___e3jd0\">\n\t\t\t<a class=\"author-bio__thumbnail___TixlC\" href=\"https:\/\/www.sciencenews.org\/author\/laura-sanders\" aria-hidden=\"true\" tabindex=\"-1\">\n\t\t\t\t\t\t\t<\/a>\n\t\t<\/figure>\n\t\n\t<div class=\"author-bio__content___F9GU3\">\n\t\t\n\n\t\t<div class=\"author-bio__bio___jkxvt\">\n\t\t\t<p>Laura Sanders is the neuroscience writer. She holds a Ph.D. in molecular biology from the University of Southern California.<\/p>\n\t\t<\/div>\n\t<\/div>\n<\/div>\n\n\t<aside class=\"sn-conversion rich-text rich-text--with-sidebar\">\n<style><![CDATA[\n.donate-box {\n  border-top: 7px solid red !important;\n  border: 1px solid #ffcccb;\n  margin-top: 50px;\n  background-color: #fdfbf2;\n  padding: 20px;\n}\n.from-nature-index__heading___AhgOe {\n  display: none;\n}\n]]><\/style>\n\n\n\n<style><![CDATA[.from-nature-index__heading___AhgOe {\n    display: none;\n}]]><\/style><div id=\"donateConversion\" class=\"wp-block-group donate-box\">\n<p class=\"has-text-align-left\" style=\"font-size:1.1em\">\nWe are at a critical time and <strong><mark>supporting science journalism \nis more important than ever<\/mark><\/strong>. <em>Science News<\/em> and our \nparent organization, the Society for Science, need your help to strengthen \nscientific literacy and ensure that important societal decisions are made \nwith science in mind.<\/p>\n\n<p class=\"has-text-align-left\" style=\"font-size:1.1em\">\nPlease \n<a href=\"https:\/\/www.sciencenews.org\/subscribe1-print-digital?key=9MENDCON&amp;utm_source=end-of-article&amp;utm_medium=site&amp;utm_campaign=non-sub-control\">\nsubscribe to <em>Science News<\/em> and <strong>add $16<\/strong><\/a> to expand \nscience literacy and understanding.\n<\/p>\n\n\n\n\n<\/div>\n<\/aside><\/footer>\n\t\t<\/div>\r\n<br>\r\n<br><a href=\"https:\/\/www.sciencenews.org\/article\/study-treat-spinal-cord-injuries-mice\">Source link <\/a>","protected":false},"excerpt":{"rendered":"<p>After a devastating spinal cord injury, mice\u2019s nerve cells balloon up in size. Some of these neurons stay swollen longer than expected and begin to die, a study published September 25 in Science Translational Medicine shows. A drug that brought this swelling down improved the mice\u2019s recovery, though it\u2019s not yet known if the approach [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":141911,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","fifu_image_url":"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2019\/08\/l_Sanders.jpg?resize=214%2C214&ssl=1","fifu_image_alt":"","footnotes":""},"categories":[606],"tags":[38881,4161,13939,2081,38880,250,4423],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/141910"}],"collection":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/comments?post=141910"}],"version-history":[{"count":1,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/141910\/revisions"}],"predecessor-version":[{"id":141912,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/141910\/revisions\/141912"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media\/141911"}],"wp:attachment":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media?parent=141910"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/categories?post=141910"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/tags?post=141910"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}