{"id":149361,"date":"2024-10-07T19:56:04","date_gmt":"2024-10-07T19:56:04","guid":{"rendered":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/10\/07\/semaglutide-saps-mices-motivation-to-run\/"},"modified":"2024-10-07T19:56:04","modified_gmt":"2024-10-07T19:56:04","slug":"semaglutide-saps-mices-motivation-to-run","status":"publish","type":"post","link":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/10\/07\/semaglutide-saps-mices-motivation-to-run\/","title":{"rendered":"Semaglutide saps mice\u2019s motivation to run"},"content":{"rendered":"<div style=\"text-align:center\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/10\/100424_ls_glp1-exercise_feat.gif?fit=800%2C450&amp;ssl=1\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Semaglutide saps mice\u2019s motivation to run\" title=\"Semaglutide saps mice\u2019s motivation to run\" \/><\/div> \r\n<br><br><div data-component=\"video-embed\">\n\t\t\t\t\n\n\n\n\n<p><strong>CHICAGO<\/strong> \u2014 Mice love to run. But not when they\u2019re taking semaglutide, the diabetes and weight-loss drug sold as Ozempic and Wegovy. While on the drug, mice ran less on a wheel in a cage, a new study shows.\u00a0\u00a0<\/p>\n\n\n\n<p>The results, presented October 7 at the annual meeting of the Society for Neuroscience, are preliminary. Still, the unexpected finding raises questions about whether such increasingly popular drugs, which <a href=\"https:\/\/www.sciencenews.org\/article\/semaglutide-wegovy-ozempic-strokes-heart#faq\">mimic a hormone called GLP-1<\/a>, might be tinkering with people\u2019s motivation to exercise (<em>SN: 8\/29\/23<\/em>).<\/p>\n\n\n<aside class=\"sn-conversion rich-text rich-text--with-sidebar\">\n<style><![CDATA[\n.email-conversion {\n  border: 1px solid #ffcccb;\n  color: white;\n  margin-top: 50px;\n  background-image: url(\"\/wp-content\/themes\/sciencenews\/client\/src\/images\/cta-module@2x.jpg\");\n  padding: 20px;\n  clear: both;\n}\n\n]]><\/style>\n\n\n\n<div class=\"rich-text embedded-conversion-content is-layout-flow wp-block-group-is-layout-flow\"><div class=\"wp-block-group__inner-container\">\n<style><![CDATA[\n#dynamic-wrapper {\n  border: 1px solid #ffcccb;\n  background-image: url(\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/03\/032624_sb_space-sugar_feat.jpg?w&#61;800&amp;ssl&#61;1\");\n  background-size: cover;\n  background-position: center center;\n  padding: 20px;\n  clear: both;\n}\n\n#dynamic-conversion {\n  padding: 20px;\n  background:rgba(0,0,0, 0.5);\n  color: white;\n}\n\n#dynamic-conversion h2 {\n  color: white;\n}\n\np.has-text-align-center a {\n  color: white !important;\n  text-decoration: none;\n  font-weight: bold;\n}\n\n]]><\/style>\n\n\n\n<div id=\"dynamic-wrapper\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-constrained wp-block-group-is-layout-constrained\">\n<div id=\"dynamic-conversion\" class=\"wp-block-group\"><div class=\"wp-block-group__inner-container is-layout-flow wp-block-group-is-layout-flow\">\n\n\n\n\n<h2 class=\"wp-block-heading has-text-align-center\"><strong>Tell us about your Science News experience<\/strong><\/h2>\n\n\n\n\n\n\n\n<p class=\"has-text-align-center\">Help us improve by taking our 15-question reader survey.<\/p>\n\n\n\n\n\n\n\n\n\n\n\n\n<\/div><\/div>\n\n\n\n\n<\/div><\/div>\n<\/div><\/div>\n\n\n\n<\/aside>\n\n\n<p>The new results fit with what\u2019s known about these drugs\u2019 abilities to change brain behavior, says neuroscientist Karolina Skibicka of Penn State University and the University of Gothenburg in Sweden. \u201cI think it\u2019s really important,\u201d she says of the new finding on exercise. \u201cI\u2019ve spent most of my career looking at these drugs. But I still think we don\u2019t know everything.\u201d<\/p>\n\n\n\n<p>Mice with unfettered access to a wheel will use it extensively, running a whopping 10 kilometers a day, says Ralph DiLeone, a neuroscientist at Yale University. \u201cIf you look at how much they\u2019re running, it\u2019s just nuts,\u201d he says.<\/p>\n\n\n\n<p>But <a href=\"https:\/\/www.abstractsonline.com\/pp8\/#!\/20433\/presentation\/18088\" target=\"_blank\" rel=\"noopener\">mice given semaglutide for seven days ran significantly less<\/a> than their usual mileage, DiLeone and colleagues found. These mice \u2014 both males and females \u2014 reduced their average daily distance by about 38 percent. When the mice went off semaglutide, their running distance snapped back to normal.<\/p>\n\n\n\n<p>As expected, the mice on semaglutide lost weight. But mice on restricted diets that lost about the same amount of weight without the drug didn\u2019t change their running habits, the researchers found. That suggests weight loss isn\u2019t causing the new sedentary behavior.<\/p>\n\n\n\n<p>Instead, this reduced running reflected a lack of motivation, further experiments suggested. Researchers trained the mice to unlock their running wheel by poking their noses into a slot, working for their workout, essentially. Mice would usually be willing to poke multiple times to unlock their running wheel. But mice on semaglutide poked less, suggesting that they were less eager to unlock their wheel.<\/p>\n\n\n\n<p>It\u2019s too soon to say whether the mice\u2019s altered running habits actually relate to the more complicated exercise decisions that people make. If these drugs do make people less motivated to exercise, Skibicka says, doctors might need to change how they talk with patients about these drugs, \u201csaying, \u2018Hey, you might feel like you don\u2019t want to exercise. But it\u2019s really important that you do.\u2019\u201d<\/p>\n\n\n\n<p>GLP-1 drugs help people lose weight, but part of that weight is muscle, Skibicka says. \u201cIf you add reduced exercise to this, now that\u2019s a problem,\u201d she says. \u201cMuscle mass is important for health. Being lean without muscle mass is not a healthy state either.\u201d<\/p>\n\n\n\n<p>But it could be that the mice\u2019s running is more like a compulsion. \u201cIt is possible that the mice are also exercising compulsively,\u201d DiLeone says, and that semaglutide may reduce this urge. That fits with other results that suggest the drug <a href=\"https:\/\/www.sciencenews.org\/article\/wegovy-ozempic-treat-addiction\">may ease addictions<\/a>, perhaps by affecting the brain\u2019s reward systems (<em>SN: 8\/30\/23<\/em>). Some people taking semaglutide have reported less desire for food, alcohol and nicotine.<\/p>\n\n\n\n<p>It\u2019s tricky to know whether these results apply to people, says exercise physiologist Glenn Gaesser of Arizona State University in Phoenix. He is not aware of any evidence that people exercise less while on these drugs. \u201cThat said, fatigue, low energy and nausea are reported side effects,\u201d and those symptoms could sap people\u2019s motivation to be active.<\/p>\n\n\n\n<p>\u201cPhysical activity and fitness have a greater impact on life span and health span than weight loss,\u201d Gaesser says. He is concerned that people who view exercise only as a weight-loss strategy \u201cmight be less inclined to be physically active after taking one of the new GLP-1 drugs by thinking, \u2018Why exercise since I can lose weight with a drug?\u2019 \u00a0That would be a big mistake.\u201d<\/p>\n\n\n\n\t\t\t<\/div>\r\n<br>\r\n<br><a href=\"https:\/\/www.sciencenews.org\/article\/semaglutide-saps-mices-motivation-run\">Source link <\/a>","protected":false},"excerpt":{"rendered":"<p>CHICAGO \u2014 Mice love to run. But not when they\u2019re taking semaglutide, the diabetes and weight-loss drug sold as Ozempic and Wegovy. While on the drug, mice ran less on a wheel in a cage, a new study shows.\u00a0\u00a0 The results, presented October 7 at the annual meeting of the Society for Neuroscience, are preliminary. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":149362,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","fifu_image_url":"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/10\/100424_ls_glp1-exercise_feat.gif?fit=800%2C450&ssl=1","fifu_image_alt":"","footnotes":""},"categories":[606],"tags":[118265,13133,3084,118264,112903],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/149361"}],"collection":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/comments?post=149361"}],"version-history":[{"count":1,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/149361\/revisions"}],"predecessor-version":[{"id":149363,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/149361\/revisions\/149363"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media\/149362"}],"wp:attachment":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media?parent=149361"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/categories?post=149361"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/tags?post=149361"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}