{"id":151981,"date":"2024-10-11T13:35:09","date_gmt":"2024-10-11T13:35:09","guid":{"rendered":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/10\/11\/radioactive-beams-give-a-real-time-view-of-cancer-treatment-in-mice\/"},"modified":"2024-10-11T13:35:09","modified_gmt":"2024-10-11T13:35:09","slug":"radioactive-beams-give-a-real-time-view-of-cancer-treatment-in-mice","status":"publish","type":"post","link":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/10\/11\/radioactive-beams-give-a-real-time-view-of-cancer-treatment-in-mice\/","title":{"rendered":"Radioactive beams give a real-time view of cancer treatment in mice"},"content":{"rendered":"<div style=\"text-align:center\"><\/div> \r\n<br><br><div data-component=\"video-embed\">\n\t\t\t\t\n\n\n\n\n<p>Cancer-busting particle beams have been caught in the act.<\/p>\n\n\n\n<p>Particle beams can provide a blast of destructive energy directly to tumors \u2014 assuming the beam is in the right place. Now, using a radioactive beam, scientists pinpointed the beam\u2019s location while treating tumors in mice. It\u2019s the first successful\u00a0<a href=\"https:\/\/arxiv.org\/abs\/2409.14898\" target=\"_blank\" rel=\"noopener\">treatment of tumors with a radioactive beam<\/a>, scientists report in a paper submitted September 23 at arXiv.org.<\/p>\n\n\n\n<p>The technique could eventually allow scientists to treat human patients with millimeter precision \u2014 particularly important when a tumor is nestled next to a sensitive organ such as the spinal cord or brain stem.<\/p>\n\n\n<aside class=\"sn-conversion rich-text rich-text--with-sidebar\">\n<style><![CDATA[\n.email-conversion {\n  border: 1px solid #ffcccb;\n  color: white;\n  margin-top: 50px;\n  background-image: url(\"\/wp-content\/themes\/sciencenews\/client\/src\/images\/cta-module@2x.jpg\");\n  padding: 20px;\n  clear: both;\n}\n\n]]><\/style>\n\n\n\n                        <style class=\"is-layout-flow 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The most common is X-rays, high-energy light that can destroy the DNA in tumor cells. But X-rays deposit their energy all along the path of the beam, resulting in potential collateral damage in other parts of the body. More precise tumor targeting is possible with particles such as protons or ions \u2014 electrically charged atoms \u2014 which dump most of their energy in one spot.\u00a0<\/p>\n\n\n\n<p>Ion treatment is currently performed at more than a dozen centers worldwide. Those treatments use stable, non-radioactive ions \u2014 typically carbon-12, a variety of carbon with six protons and six neutrons in its nucleus. The particles in the beam have their electrons stripped off, giving them a positive charge.\u00a0<\/p>\n\n\n\n<p>The tumor is targeted based on calculations of how deep a beam will penetrate, coupled with previous\u00a0<a href=\"https:\/\/www.sciencenews.org\/article\/ct-scan-50-years-anniversary-first-image-medicine-physics\">imaging of the patient<\/a>, for example, a CT scan (<em>SN: 12\/10\/21<\/em>). But bodies are not rigid, and organs can shift between imaging and treatment. Ideally, the beam\u2019s position would be confirmed in real time. That\u2019s just what the new technique allows.<\/p>\n\n\n\n<p>\u201cIf you use a radioactive ion, you can simultaneously kill the tumor and see the beam,\u201d says physicist Marco Durante of GSI Helmholtz Centre for Heavy Ion Research in Darmstadt, Germany.<\/p>\n\n\n\n<p>Durante and colleagues used carbon-11 ions, which have one fewer neutron in their atomic nuclei than carbon-12 ions do, making them radioactive. When carbon-11 decays, it releases a positron \u2014 a positively charged antimatter partner of an electron. Scientists can detect that positron annihilating with an electron in the body, via\u00a0<a href=\"https:\/\/www.sciencenews.org\/article\/ways-seeing-brain-inspire-notions-how-it-works\">positron emission tomography<\/a>, or PET (<em>SN: 2\/13\/14<\/em>). That identifies where the beam dumps its particles.\u00a0<\/p>\n\n\n\n<p>In the study, scientists used the carbon-11 ions to treat mice with tumors near the spine. Scientists were able to check the position of the beam during treatment and confirm that it was spot-on. Sure enough, the treatment shrunk the tumors.\u00a0\u00a0<\/p>\n\n\n\n<p>Scientists had already tried to use PET to measure the location of a beam of stable ions. The stable ions don\u2019t emit positrons, but some of the stable atomic nuclei break apart as they pass through material. Those fragments can make radioactive ions that release positrons in their decays. But the technique is difficult as the number of such particles is small.\u00a0<\/p>\n\n\n\n<p>With radioactive ion beams, many more positrons are emitted. \u201cThat allows [you] to get a very crisp and beautiful image of where the particle stops,\u201d says radiation physicist Mitra Safavi-Naeini of Australia\u2019s Nuclear Science and Technology Organisation in Sydney, who was not involved with the research.<\/p>\n\n\n\n<p>The technique could also help scientists understand how radioactive material moves through the body after an ion treatment, Safavi-Naeini says. The radioactive particles are washed out of the beam\u2019s bull\u2019s-eye by blood flowing through the body. This spreads out the positron signal over time. The amount of this washout could help scientists understand if blood vessels are being destroyed by the treatment, thereby cutting off the tumor\u2019s energy supply. This could help scientists understand how best to use particle beams to ensure the cancer\u2019s demise.\u00a0<\/p>\n\n\n\n\t\t\t<\/div>\r\n<br>\r\n<br><a href=\"https:\/\/www.sciencenews.org\/article\/radioactive-ion-cancer-treatment\">Source link <\/a>","protected":false},"excerpt":{"rendered":"<p>Cancer-busting particle beams have been caught in the act. Particle beams can provide a blast of destructive energy directly to tumors \u2014 assuming the beam is in the right place. Now, using a radioactive beam, scientists pinpointed the beam\u2019s location while treating tumors in mice. It\u2019s the first successful\u00a0treatment of tumors with a radioactive beam, [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":151982,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","fifu_image_url":"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/10\/101024_ec_ion-beam-cancer-treatment_feat.jpg?fit=800%2C450&ssl=1","fifu_image_alt":"","footnotes":""},"categories":[606],"tags":[61827,281,2739,2081,95191,25509,7146,5258],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/151981"}],"collection":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/comments?post=151981"}],"version-history":[{"count":1,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/151981\/revisions"}],"predecessor-version":[{"id":151983,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/151981\/revisions\/151983"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media\/151982"}],"wp:attachment":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media?parent=151981"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/categories?post=151981"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/tags?post=151981"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}