{"id":22309,"date":"2024-04-09T15:39:59","date_gmt":"2024-04-09T15:39:59","guid":{"rendered":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/04\/09\/a-protein-found-in-sweat-may-protect-people-from-lyme-disease\/"},"modified":"2024-04-09T15:39:59","modified_gmt":"2024-04-09T15:39:59","slug":"a-protein-found-in-sweat-may-protect-people-from-lyme-disease","status":"publish","type":"post","link":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/04\/09\/a-protein-found-in-sweat-may-protect-people-from-lyme-disease\/","title":{"rendered":"A protein found in sweat may protect people from Lyme disease"},"content":{"rendered":"<div style=\"text-align:center\"><\/div> \r\n<br><br><div data-component=\"video-embed\">\n\t\t\t\t\n\n\n\n\n<p>Breaking into a cold sweat over a tick bite may have its benefits.<\/p>\n\n\n\n<p>A protein found in human sweat could <a href=\"https:\/\/www.nature.com\/articles\/s41467-024-45983-9\" target=\"_blank\" rel=\"noopener\">offer some protection against <em>Borrelia burgdorferi<\/em><\/a>, a tick-transmitted bacterium that causes Lyme disease, researchers report March 19 in <em>Nature Communications<\/em>. In lab dishes and mice, the protein curbed bacterial growth. But some people have a mutated version of the protein that doesn\u2019t work as well, perhaps putting them at higher risk of becoming infected.<\/p>\n\n\n\n<p>\u201cWhen we talk about risk factors for [contracting] Lyme, we generally talk about camping, golfing, maybe gardening,\u201d says MIT immunologist Michal Tal. But sweaty activities like trail running aren\u2019t typically on the list. \u201cIt\u2019s never even been a question of whether or not it mattered if you were sweating, and if you had any protection in your sweat.\u201d\u00a0<\/p>\n\n\n<aside class=\"sn-conversion rich-text rich-text--with-sidebar\">\n<style><![CDATA[\n.email-conversion {\n  border: 1px solid #ffcccb;\n  color: white;\n  margin-top: 50px;\n  background-image: url(\"\/wp-content\/themes\/sciencenews\/client\/src\/images\/cta-module@2x.jpg\");\n  padding: 20px;\n  clear: both;\n}\n\n]]><\/style>\n\n\n\n                        <style class=\"is-layout-flow wp-block-group-is-layout-flow\"><![CDATA[.zephr-payment-form.svelte-13h66j{margin:20px auto;padding:20px;background-color:#fff;font-family:var(--zephr-typography-body-font),\n            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none;\n}\n.zephr-payment-form-checkbox-label.svelte-eq3e4e {\n    display: flex;\n    align-items: center;\n    font-family: var(--zephr-typography-body-font), var(--zephr-typography-body-fallbackFont);\n    color: white;\n    font-weight: bold;\n}]]><\/style>\n                        \n                        \n\n<\/aside>\n\n\n<p>Tal and colleagues aimed to find genes that may make some people more susceptible to Lyme disease. The team analyzed genetic data from about 620,000 people who\u2019d been seen at hospitals or primary care clinics in Finland and Estonia. More than 25,000 of those individuals had been diagnosed with Lyme disease.<\/p>\n\n\n\n<p>The analysis uncovered three candidate genes. Two genes provide the instructions to make immune proteins that help the body identify foreign invaders. The third gene codes for SCGB1D2, \u201ca totally unexpected protein that \u2026 we didn\u2019t really know anything about,\u201d says geneticist Hanna Ollila of the University of Helsinki. The team eventually figured out that the protein is made in sweat glands and may show up on the skin \u2014 the first line of defense against hungry ticks.<\/p>\n\n\n\n<p>In lab dishes, the protein stopped <em>B. burgdorferi<\/em> from growing. What\u2019s more, mice injected with the protein plus the bacteria didn\u2019t become infected.<\/p>\n\n\n\n<p>However, 40 percent of people in the study carried a mutated version of the protein. In experiments with that variant, twice as much protein was required to curb bacterial growth in lab dishes. And mice injected with the variant alongside the bacteria developed infections.<\/p>\n\n\n\n<p>The results, the researchers say, suggest that the normal version of SCGB1D2 could someday be leveraged as a treatment for Lyme disease, the <a href=\"https:\/\/www.sciencenews.org\/article\/ticks-lyme-disease-testing-new-approaches\">most common tickborne infection in the United States<\/a> and Europe (<em>SN: 6\/23\/19<\/em>). The protein might also be used as a preventative to stop <em>B. burgdorferi<\/em> from taking hold. But that would take a bit of engineering. \u201cThere\u2019s still a lot of work that remains to be done for us to see just how much potential it has,\u201d Tal says.<\/p>\n\n\n\n<p>The finding raises questions about how the protein might interact with bacteria once a tick digs in for a bite, says medical entomologist Adela Oliva Ch\u00e1vez of the University of Wisconsin\u2013Madison. Tal\u2019s team exposed mice to the bacteria via needle injections, bypassing any <a href=\"https:\/\/www.sciencenews.org\/article\/how-ticks-gene-protein-protection-bacteria-human-skin\">tactics the tick might have<\/a> to make SCGB1D2 less effective (<em>SN: 12\/10\/20<\/em>). <\/p>\n\n\n\n<p>Though there are still many unknowns, \u201cI\u2019m excited, with caution,\u201d Oliva Ch\u00e1vez says.<\/p>\n\n\n\n\t\t\t<\/div>\r\n<br>\r\n<br><a href=\"https:\/\/www.sciencenews.org\/article\/lyme-disease-sweat-protection-ticks-bacteria\">Source link <\/a>","protected":false},"excerpt":{"rendered":"<p>Breaking into a cold sweat over a tick bite may have its benefits. A protein found in human sweat could offer some protection against Borrelia burgdorferi, a tick-transmitted bacterium that causes Lyme disease, researchers report March 19 in Nature Communications. In lab dishes and mice, the protein curbed bacterial growth. But some people have a [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":22310,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","fifu_image_url":"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/03\/032724_eg_tick_lyme_protein_feat.jpg?fit=800%2C450&ssl=1","fifu_image_alt":"","footnotes":""},"categories":[606],"tags":[8069,10319,124,713,3398,10318],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/22309"}],"collection":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/comments?post=22309"}],"version-history":[{"count":1,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/22309\/revisions"}],"predecessor-version":[{"id":22311,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/22309\/revisions\/22311"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media\/22310"}],"wp:attachment":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media?parent=22309"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/categories?post=22309"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/tags?post=22309"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}