{"id":253412,"date":"2025-03-06T20:56:07","date_gmt":"2025-03-06T20:56:07","guid":{"rendered":"https:\/\/news.talkwithrattan.com\/index.php\/2025\/03\/06\/how-a-labrador-retrievers-genes-might-affect-the-dogs-obesity-risk\/"},"modified":"2025-03-06T20:56:07","modified_gmt":"2025-03-06T20:56:07","slug":"how-a-labrador-retrievers-genes-might-affect-the-dogs-obesity-risk","status":"publish","type":"post","link":"https:\/\/news.talkwithrattan.com\/index.php\/2025\/03\/06\/how-a-labrador-retrievers-genes-might-affect-the-dogs-obesity-risk\/","title":{"rendered":"How a Labrador retriever\u2019s genes might affect the dog\u2019s obesity risk"},"content":{"rendered":"<div style=\"text-align:center\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2025\/03\/030625_av_obese-labradors_feat.jpg?fit=800%2C450&amp;ssl=1\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"How a Labrador retriever\u2019s genes might affect the dog\u2019s obesity risk\" title=\"How a Labrador retriever\u2019s genes might affect the dog\u2019s obesity risk\" \/><\/div> \r\n<br><br><div data-component=\"video-embed\">\n\t\t\t\t\n\n\n\n\n<p>Labrador retriever owners are likely familiar with how persistent their dogs can be in their quest for food, whether begging under the dinner table or stealing a snack left unattended. It\u2019s no surprise, then, that Labs are among the <a href=\"https:\/\/onlinelibrary.wiley.com\/doi\/10.1111\/jsap.13325\" target=\"_blank\" rel=\"noopener\">most overweight dog breeds<\/a>, along with golden retrievers, cocker spaniels and beagles.<\/p>\n\n\n\n<p>Scientists have now <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.ads2145\" target=\"_blank\" rel=\"noopener\">identified multiple genes associated with obesity in Labradors<\/a>, according to a March 6 study in <em>Science<\/em>.<\/p>\n\n\n\n<p>The researchers had previously found that a <a href=\"https:\/\/www.sciencenews.org\/blog\/science-ticker\/why-labrador-retrievers-are-obsessed-food\" data-type=\"link\" data-id=\"https:\/\/www.sciencenews.org\/blog\/science-ticker\/why-labrador-retrievers-are-obsessed-food\">form of a gene called <em>POMC<\/em><\/a> made Labs more prone to overeating. But \u201cwe could tell from our studies that the <em>POMC<\/em> mutation wasn\u2019t the whole story,\u201d says Eleanor Raffan, a veterinary surgeon and geneticist at the University of Cambridge.<\/p>\n\n\n<aside class=\"sn-conversion rich-text rich-text--with-sidebar\">\n<style><![CDATA[\n.email-conversion {\n  border: 1px solid #ffcccb;\n  color: white;\n  margin-top: 50px;\n  background-image: url(\"\/wp-content\/themes\/sciencenews\/client\/src\/images\/cta-module@2x.jpg\");\n  padding: 20px;\n  clear: both;\n}\n\n]]><\/style>\n\n\n\n                        <style class=\"is-layout-flow 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5px}.zephr-form-input-inner-text{color:var(--zephr-color-text-main);font-size:var(--zf-subtext-fontSize);font-weight:bold;font-family:var(--zf-root-fontFamily)}\n]]><\/style>\n                        \n                        <style><![CDATA[label {\n    display: none !important;\n}\n\n#coppa {\n    font-size: 10px;\n    font-weight: normal;\n    color: white;\n    padding: 10px;\n}\n\n#coppa>a {\n    color: white !important;\n}\n\n.zephr-form-button {\n    background-color: #d4441f !important;\n    text-transform: uppercase !important;\n    font-weight: 900 !important;\n    letter-spacing: 0.075em;\n    font-size: 1.2em !important;\n    border: 2px solid black !important;\n}\n\n.zephr-form {\n    border: 1px solid #ffcccb;\n    background-image: url(\"https:\/\/preprod.sciencenews.org\/wp-content\/uploads\/2024\/10\/astro.jpg\");\n    background-size: cover;\n    background-position: left top;\n    background-image:url(\"https:\/\/www.sciencenews.org\/wp-content\/uploads\/2024\/11\/cta_background_webb-tarantula-neb.jpg\");\n    padding: 20px;\n    padding-top: 40px;\n}\n\n.zephr-form {\n    --zf-container-bgColor: none;\n    --zf-container-maxWidth: 900px;\n}\n\n.zephr-form-input {\n    font-size: 1.5rem !important;\n    font-family: monospace !important;\n    filter: drop-shadow(black .1rem .1rem 5px);\n}\n\n.zephr-form-error-message {\n    background-color:white; \n    padding:5px; \n    font-weight:bold\n}\n\n.zephr-form-input::placeholder {\n    font-family: \"Courier New\" !important;\n    color: #999 !important;\n}]]><\/style>\n                        \n                        \n<\/aside>\n\n\n<p>In the new study, Raffan and her colleagues examined DNA samples from 241 British Labrador retrievers. The researchers also collected information including the dogs\u2019 body fat mass, how much dogs begged for food, and how strictly their owners regulated their diet.<\/p>\n\n\n\n<p>The researchers uncovered five genes potentially associated with obesity in the dogs. The strongest effect came from a gene called <em>DENND1B<\/em> \u2014 Labradors with a certain variant of this gene had around 8 percent more body fat than dogs without it<strong>. <\/strong><em>DENND1B<\/em>, which affects how the brain\u2019s responds to food, was also associated with higher body mass indexes in humans.<\/p>\n\n\n\n<p>Knowing which genes were associated with obesity allowed Raffan and her colleagues to develop a risk scoring system, which helped calculate whether individual Labradors were at higher or lower risk of obesity based on their genetic profile.<\/p>\n\n\n\n<p>\u201cYou can rank all of the individuals in the population based on whether they inherited a bunch of obesity-prone genes, or maybe they didn\u2019t inherit many at all,\u201d says Adam Boyko, a canine geneticist at Cornell University who was not involved with the study.<\/p>\n\n\n\n<p>With this information, the researchers could see how high-risk and low-risk Labradors differed when it came to their relationships with food. Labradors at a high risk for obesity, for example, were more likely to beg and to be more driven toward finding food. And for Labradors that were more genetically predisposed to obesity, owners who were stricter about regulating their pets\u2019 diet made all the difference.<\/p>\n\n\n\n<p>\u201cIf you\u2019re a high-risk dog and your owner is really strict with the management, you can be a perfectly healthy body weight,\u201d Raffan says. \u201cBut if they\u2019re pretty relaxed about the management, those are the dogs who get overweight.\u201d She added that dogs with a lower genetic risk tended to stay at a fairly healthy weight, regardless of how their owner fed them.<\/p>\n\n\n\n<p>So do you need a genetic test to determine whether your Labrador may be at risk for obesity? Probably not, says Raffan. If a dog seems like it would tip the scales if given the chance to plan its own diet, that could be a hint that their genes may be behind its drive for food. Trying to ration food for dogs that pack on the pounds could be a safe bet \u2014 though it\u2019s often easier said than done. \u201cTo be disciplined about your dog\u2019s food intake, it sounds straightforward, but it\u2019s actually quite a tough job if you\u2019ve got one of these massively food-motivated pets,\u201d Raffan says.<\/p>\n\n\n\n\n\n\n\n\t\t\t<\/div>\r\n<br>\r\n<br><a href=\"https:\/\/www.sciencenews.org\/article\/labrador-retrievers-genes-obesity-risk\">Source link <\/a>","protected":false},"excerpt":{"rendered":"<p>Labrador retriever owners are likely familiar with how persistent their dogs can be in their quest for food, whether begging under the dinner table or stealing a snack left unattended. It\u2019s no surprise, then, that Labs are among the most overweight dog breeds, along with golden retrievers, cocker spaniels and beagles. Scientists have now identified [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":253413,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","fifu_image_url":"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2025\/03\/030625_av_obese-labradors_feat.jpg?fit=800%2C450&ssl=1","fifu_image_alt":"","footnotes":""},"categories":[606],"tags":[5772,2408,9917,196092,7874,196093,1115],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/253412"}],"collection":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/comments?post=253412"}],"version-history":[{"count":1,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/253412\/revisions"}],"predecessor-version":[{"id":253414,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/253412\/revisions\/253414"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media\/253413"}],"wp:attachment":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media?parent=253412"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/categories?post=253412"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/tags?post=253412"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}