{"id":57274,"date":"2024-05-23T15:50:01","date_gmt":"2024-05-23T15:50:01","guid":{"rendered":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/05\/23\/biological-puzzles-abound-in-an-up-close-look-at-a-human-brain\/"},"modified":"2024-05-23T15:50:01","modified_gmt":"2024-05-23T15:50:01","slug":"biological-puzzles-abound-in-an-up-close-look-at-a-human-brain","status":"publish","type":"post","link":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/05\/23\/biological-puzzles-abound-in-an-up-close-look-at-a-human-brain\/","title":{"rendered":"Biological puzzles abound in an up-close look at a human brain"},"content":{"rendered":"<div style=\"text-align:center\"><img decoding=\"async\" src=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_inline.jpg?resize=680%2C408&amp;ssl=1\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Biological puzzles abound in an up-close look at a human brain\" title=\"Biological puzzles abound in an up-close look at a human brain\" \/><\/div> \r\n<br><div data-component=\"video-embed\">\n\t\t\t\t\n\n\n\n\n<p>It\u2019s a bit like seeing a world in a grain of sand.<\/p>\n\n\n\n<p>Except the view, in this case, is <a href=\"https:\/\/www.science.org\/doi\/10.1126\/science.adk4858\" target=\"_blank\" rel=\"noopener\">the exquisite detail inside a bit of human brain<\/a> about half the size of a grain of rice. Held in that minuscule object is a complex collective of cells, blood vessels, intricate patterns and biological puzzles.<\/p>\n\n\n\n<p>Scientists had hints of these mysteries in <a href=\"https:\/\/www.sciencenews.org\/article\/brain-map-neurons-connections-google-harvard\">earlier peeks at this bit of brain<\/a> (<em>SN: 6\/29\/21<\/em>). But now, those details have been brought into new focus by mapping the full landscape of some 57,000 cells, 150 million synapses and their accompanying 23 centimeters of blood vessels, researchers report in the May 10 <em>Science<\/em>. The full results, the scientists hope, may lead to greater insights into how the human brain works.<\/p>\n\n\n<aside class=\"sn-conversion rich-text rich-text--with-sidebar\">\n<style><![CDATA[\n.email-conversion {\n  border: 1px solid #ffcccb;\n  color: white;\n  margin-top: 50px;\n  background-image: url(\"\/wp-content\/themes\/sciencenews\/client\/src\/images\/cta-module@2x.jpg\");\n  padding: 20px;\n  clear: both;\n}\n\n]]><\/style>\n\n\n\n                        <style class=\"is-layout-flow 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unset);line-height:unset;margin:unset;padding:unset;border:unset;background:unset;&:hover, &:focus-visible {\n            border: unset;\n            background: unset;\n        }}.zephr-form-disabled-div{pointer-events:none;opacity:0.8}.zephr-form-relative-container{position:relative}.zephr-form-flex-container{display:flex}.zephr-form-input-inner-button{cursor:pointer;position:absolute;top:50%;transform:translateY(-50%);right:5px;padding:10px 5px}.zephr-form-input-inner-text{color:var(--zephr-color-text-main);font-size:var(--zf-subtext-fontSize);font-weight:bold;font-family:var(--zf-root-fontFamily)}\n]]><\/style>\n                        \n                        <style><![CDATA[.zephr-form-max-width.zephr-payment-form-max-width {\n    background-image: url(https:\/\/www.sciencenews.org\/wp-content\/themes\/sciencenews\/client\/src\/images\/cta-module@2x.jpg);\n    padding:20px;\n    max-width: 100%;\n}\n\n.zephr-form-custom-text > p {\n    display: none;\n}\n\nform.zephr-form-content {\n    opacity: .9;\n}\n\nlabel.zephr-form-checkbox-label {\n    font-size: 1.2rem;\n    font-weight: bolder;\n}\n\n.zephr-form-custom-text > h4 {\n    color: black !important;\n}\n\nbutton.zephr-form-button {\n    background: #d4441f !important;\n    font-weight: bold !important;\n    text-transform: uppercase !important;\n}\n\nlabel.zephr-payment-form-checkbox-label {\n    color: white;\n    font-size: 1.6rem;\n}\n\n.zephr-form-content {\n    background:#2f537f;\n    \n}\n\n.zephr-payment-form-custom-text {\n    margin-top: .2rem;\n}\n\n.zephr-payment-form-checkbox-label {\n    display: flex;\n    align-items: center;\n    font-family: var(--zephr-typography-body-font), var(--zephr-typography-body-fallbackFont);\n    color: white;\n    font-weight: bold;\n}]]><\/style>\n                        \n                        \n<\/aside>\n\n\n<p>\u201cWe\u2019re going in and looking at every individual connection attached to every cell \u2014 a very high level of detail,\u201d says Viren Jain, a computational neuroscientist at Google Research in Mountain View, Calif. The big-picture goal of brain mapping efforts, he says, is \u201cto understand how human brains work and what goes wrong in various kinds of brain diseases.\u201d<\/p>\n\n\n\n<p>The newly mapped brain sample was removed during a woman\u2019s surgery for epilepsy, so that doctors could reach a deeper part of the brain. The bit, donated with the woman\u2019s consent, was from the temporal lobe of the cortex, the outer part of the brain involved in complex mental feats like thinking, remembering and perceiving.<\/p>\n\n\n\n<figure class=\"wp-block-image size-full\"><figcaption class=\"wp-element-caption\"><span class=\"caption wp-caption-3139741\">During surgery for epilepsy, a surgeon removed a bit of a woman\u2019s brain, a piece that became the starting material for this brain map.<\/span><span class=\"credit wp-credit-3139741\">Google<\/span><\/figcaption><\/figure>\n\n\n\n<p>After being fixed in a preservative, the brain bit was sliced into almost impossibly thin wisps, and then each slice was imaged with a high-powered microscope. Once these views were collected, researchers used computers to digitally reconstruct the three-dimensional objects embedded in the piece of brain.<\/p>\n\n\n\n<p>Some of those objects were surprising. Certain nerve cell pairs had extremely tight bonds, making 50 or more contact points with each other. \u201cThis is like if two houses in the neighborhood for some reason had 50 different phones connecting just those two houses,\u201d Jain says. \u201cIt\u2019s like, what\u2019s going on here?\u201d<\/p>\n\n\n\n<div class=\"slideshow__container___2inGd\" data-component=\"slideshow\">\n\t\n\n\t<ol class=\"slideshow__slides___BfLMo\">\n\t\t\n<li class=\"slideshow__wrapper___Aebb- item-1\" role=\"listitem\">\n\t<figure class=\"slideshow__figure___DHfIZ\">\n\t\t<img decoding=\"async\" width=\"680\" height=\"370\" class=\"attachment-medium size-medium\" alt=\"Blue, yellow, orange and red nerve cells with long tendrils are packed together in this digital reconstruction of brain tissue.\" loading=\"lazy\" data-attachment-id=\"3139742\" src=\"https:\/\/www.sciencenews.org\/051624_ls_brain_map_slideshow1\" data-orig-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow1.jpg?fit=680%2C370&amp;ssl=1\" data-orig-size=\"680,370\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"051624_ls_brain_map_slideshow1\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;These nerve cells are all excitatory, which means they send signals to other cells that spur them into action. Their colors indicate different sizes of the main cell bodies.&lt;\/p&gt;&#10;\" data-medium-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow1.jpg?fit=680%2C370&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow1.jpg?fit=680%2C370&amp;ssl=1\"\/>\n\t\t\n\t\t\t<figcaption class=\"slideshow__gallery-caption___jcoF1\">\n\t\t\t\t<span class=\"caption\">These nerve cells are all excitatory, which means they send signals to other cells that spur them into action. Their colors indicate different sizes of the main cell bodies.<\/span>\t\t\t\t<span class=\"credit\">Google Research and Lichtman Lab\/Harvard University; Rendering by D. Berger\/Harvard University<\/span>\t\t\t<\/figcaption>\n\n\t\t\t<\/figure>\n\n<\/li>\n<li class=\"slideshow__wrapper___Aebb- item-2\" role=\"listitem\">\n\t<figure class=\"slideshow__figure___DHfIZ\">\n\t\t<img decoding=\"async\" width=\"680\" height=\"370\" class=\"attachment-medium size-medium\" alt=\"A triangular-shaped nerve cell is surrounded by blue thin axons on of its branches.\" loading=\"lazy\" data-attachment-id=\"3139743\" src=\"https:\/\/www.sciencenews.org\/051624_ls_brain_map_slideshow2\" data-orig-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow2.jpg?fit=680%2C370&amp;ssl=1\" data-orig-size=\"680,370\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"051624_ls_brain_map_slideshow2\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;This nerve cell (white) is intensely connected with other cells. Shown here are contacts from 5,600 message-sending axons (blue).&lt;\/p&gt;&#10;\" data-medium-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow2.jpg?fit=680%2C370&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow2.jpg?fit=680%2C370&amp;ssl=1\"\/>\n\t\t\n\t\t\t<figcaption class=\"slideshow__gallery-caption___jcoF1\">\n\t\t\t\t<span class=\"caption\">This nerve cell (white) is intensely connected with other cells. Shown here are contacts from 5,600 message-sending axons (blue).<\/span>\t\t\t\t<span class=\"credit\">Google Research and Lichtman Lab\/Harvard University; Rendering by D. Berger\/Harvard University<\/span>\t\t\t<\/figcaption>\n\n\t\t\t<\/figure>\n\n<\/li>\n<li class=\"slideshow__wrapper___Aebb- item-3\" role=\"listitem\">\n\t<figure class=\"slideshow__figure___DHfIZ\">\n\t\t<img decoding=\"async\" width=\"680\" height=\"370\" class=\"attachment-medium size-medium\" alt=\"A green strand with little bulges along it is touched by a thinner blue strand, showing where two nerve cells touch.\" loading=\"lazy\" data-attachment-id=\"3139744\" src=\"https:\/\/www.sciencenews.org\/051624_ls_brain_map_slideshow3\" data-orig-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow3.jpg?fit=680%2C370&amp;ssl=1\" data-orig-size=\"680,370\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"051624_ls_brain_map_slideshow3\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;This message-sending axon (blue) contacts a target cell\u2019s dendrite (green) many times, creating what might be an unusually strong connection between two nerve cells.&lt;\/p&gt;&#10;\" data-medium-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow3.jpg?fit=680%2C370&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow3.jpg?fit=680%2C370&amp;ssl=1\"\/>\n\t\t\n\t\t\t<figcaption class=\"slideshow__gallery-caption___jcoF1\">\n\t\t\t\t<span class=\"caption\">This message-sending axon (blue) contacts a target cell\u2019s dendrite (green) many times, creating what might be an unusually strong connection between two nerve cells.<\/span>\t\t\t\t<span class=\"credit\">Google Research and Lichtman Lab\/Harvard University; Rendering by D. Berger\/Harvard University<\/span>\t\t\t<\/figcaption>\n\n\t\t\t<\/figure>\n\n<\/li>\n<li class=\"slideshow__wrapper___Aebb- item-4\" role=\"listitem\">\n\t<figure class=\"slideshow__figure___DHfIZ\">\n\t\t<img decoding=\"async\" width=\"680\" height=\"370\" class=\"attachment-medium size-medium\" alt=\"A nerve cell colored yellow on the top is the mirror image of a nerve cell colored pink on the bottom. Both cells have complex branching shapes.\" loading=\"lazy\" data-attachment-id=\"3139745\" src=\"https:\/\/www.sciencenews.org\/051624_ls_brain_map_slideshow4\" data-orig-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow4.jpg?fit=680%2C370&amp;ssl=1\" data-orig-size=\"680,370\" data-comments-opened=\"0\" data-image-meta=\"{&quot;aperture&quot;:&quot;0&quot;,&quot;credit&quot;:&quot;&quot;,&quot;camera&quot;:&quot;&quot;,&quot;caption&quot;:&quot;&quot;,&quot;created_timestamp&quot;:&quot;0&quot;,&quot;copyright&quot;:&quot;&quot;,&quot;focal_length&quot;:&quot;0&quot;,&quot;iso&quot;:&quot;0&quot;,&quot;shutter_speed&quot;:&quot;0&quot;,&quot;title&quot;:&quot;&quot;,&quot;orientation&quot;:&quot;0&quot;}\" data-image-title=\"051624_ls_brain_map_slideshow4\" data-image-description=\"\" data-image-caption=\"&lt;p&gt;The new brain map turned up pairs of nerve cells with eerily similar mirror-image shapes. It\u2019s unknown how these cells create this symmetry, or why it happens.&lt;\/p&gt;&#10;\" data-medium-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow4.jpg?fit=680%2C370&amp;ssl=1\" data-large-file=\"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_slideshow4.jpg?fit=680%2C370&amp;ssl=1\"\/>\n\t\t\n\t\t\t<figcaption class=\"slideshow__gallery-caption___jcoF1\">\n\t\t\t\t<span class=\"caption\">The new brain map turned up pairs of nerve cells with eerily similar mirror-image shapes. It\u2019s unknown how these cells create this symmetry, or why it happens.<\/span>\t\t\t\t<span class=\"credit\">Google Research and Lichtman Lab\/Harvard University; Rendering by D. Berger\/Harvard University<\/span>\t\t\t<\/figcaption>\n\n\t\t\t<\/figure>\n\n<\/li>\t<\/ol>\n<\/div>\n\n\n\n<p>Other views revealed mysterious whorls formed by message-sending tendrils called axons. \u201cThe axon would loop in on itself and make a giant knot,\u201d Jain says. \u201cWe definitely didn\u2019t expect to see these.\u201d Scientists don\u2019t know why these swirls exist.<\/p>\n\n\n\n<p>And some nerve cells in the deepest layer of the brain bit appear to have mirror-image twins \u2014 another mystery.<\/p>\n\n\n\n<p>These results don\u2019t necessarily change the view of how the brain works. \u201cIt\u2019s more like, \u2018Oh, we\u2019ve found this new structure in nature. Maybe there\u2019s something really important about it. We\u2019ll have to study it further,\u2019\u201d Jain says. Next up, he says, is scaling up to create a similar map for a piece of mouse brain that\u2019s 10 to 15 times bigger than the piece used in the new study. Researchers also hope to map more human brain samples.<\/p>\n\n\n\n\t\t\t<\/div>\r\n<br>\r\n<br><a href=\"https:\/\/www.sciencenews.org\/article\/biological-puzzles-human-brain-visual\">Source link <\/a>","protected":false},"excerpt":{"rendered":"<p>It\u2019s a bit like seeing a world in a grain of sand. Except the view, in this case, is the exquisite detail inside a bit of human brain about half the size of a grain of rice. Held in that minuscule object is a complex collective of cells, blood vessels, intricate patterns and biological puzzles. [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":57275,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","fifu_image_url":"https:\/\/i0.wp.com\/www.sciencenews.org\/wp-content\/uploads\/2024\/05\/051624_ls_brain_map_inline.jpg?resize=680%2C408&ssl=1","fifu_image_alt":"","footnotes":""},"categories":[606],"tags":[56095,2119,1920,4261,56094,56096],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/57274"}],"collection":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/comments?post=57274"}],"version-history":[{"count":1,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/57274\/revisions"}],"predecessor-version":[{"id":57276,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/57274\/revisions\/57276"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media\/57275"}],"wp:attachment":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media?parent=57274"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/categories?post=57274"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/tags?post=57274"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}