{"id":71638,"date":"2024-06-12T22:57:07","date_gmt":"2024-06-12T22:57:07","guid":{"rendered":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/06\/12\/akira-endo-scholar-of-statins-that-reduce-heart-disease-dies-at-90\/"},"modified":"2024-06-12T22:57:07","modified_gmt":"2024-06-12T22:57:07","slug":"akira-endo-scholar-of-statins-that-reduce-heart-disease-dies-at-90","status":"publish","type":"post","link":"https:\/\/news.talkwithrattan.com\/index.php\/2024\/06\/12\/akira-endo-scholar-of-statins-that-reduce-heart-disease-dies-at-90\/","title":{"rendered":"Akira Endo, Scholar of Statins That Reduce Heart Disease, Dies at 90"},"content":{"rendered":"<div style=\"text-align:center\"><img loading=\"lazy\" decoding=\"async\" width=\"1050\" height=\"549\" src=\"https:\/\/i0.wp.com\/static01.nyt.com\/images\/2024\/06\/12\/multimedia\/12XP-ENDO-gztp\/12XP-ENDO-gztp-facebookJumbo.jpg?fit=1050,549&amp;ssl=1\" class=\"attachment-post-thumbnail size-post-thumbnail wp-post-image\" alt=\"Akira Endo, Scholar of Statins That Reduce Heart Disease, Dies at 90\" title=\"Akira Endo, Scholar of Statins That Reduce Heart Disease, Dies at 90\" \/><\/div><p> <br \/>\n<\/p>\n<div>\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Akira Endo, a Japanese biochemist whose research on fungi helped to lay the groundwork for widely prescribed drugs that lower a type of cholesterol that contributes to heart disease, died on June 5. He was 90.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Chiba Kazuhiro, the president of Tokyo University of Agriculture and Technology, where Dr. Endo was a professor emeritus, <a class=\"css-yywogo\" href=\"https:\/\/www.tuat.ac.jp\/NEWS\/info\/20240611_01.html\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">confirmed the death in a statement<\/a>. The statement did not give a cause or say where he died.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Cholesterol, mostly made in the liver, has important functions in the body. It is also a major contributor to coronary artery disease, a leading <a class=\"css-yywogo\" href=\"https:\/\/www.cdc.gov\/heart-disease\/data-research\/facts-stats\/index.html\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">cause of death in the United States<\/a>, Japan and many other countries.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">In the early 1970s, Dr. Endo grew fungi in an effort to find a natural substance that could block a crucial enzyme that is part of the production of cholesterol. Some scientists worried that doing so might threaten cholesterol\u2019s positive functions.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div>\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">But by 1980, Dr. Endo\u2019s team had found that a cholesterol-lowering drug, or statin, lowered the LDL, or \u201cbad\u201d cholesterol level, in the blood. And by 1987, after other researchers in the field had published additional research on statins, Merck was manufacturing the first licensed statin.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Such drugs have proven effective in reducing the risk for cardiovascular disease, and millions of people in the United States and beyond now take them for high levels of LDL.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Akira Endo was born on Nov. 14, 1933, in Yurihonjo, a city in a mountainous area near the Sea of Japan. His parents were farmers, and he developed an interest in mushrooms and molds \u2014 one that would influence his work as a scientist.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">He worked in rice fields by day and attended high school, against his parents\u2019 wishes, by night. He was inspired partly by a desire to help farmers struggling with agricultural pests, said Kozo Sasada, a spokesman for Endo Akira Kenshokai, a group that honors Dr. Endo\u2019s legacy.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Endo said his career was also inspired by a biography he read of Sir Alexander Fleming, a Scottish biologist who discovered penicillin in the 1920s.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div>\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cFor me Fleming was a hero,\u201d Dr. Endo <a class=\"css-yywogo\" href=\"https:\/\/www.igaku-shoin.co.jp\/paper\/archive\/y2014\/PA03080_01\" title=\"\" rel=\"noopener noreferrer\" target=\"_blank\">told Igaku-Shoin<\/a>, a Japanese medical publisher, in 2014. \u201cI dreamed of becoming a doctor as a child, but realized a new horizon as people who are not doctors can save people\u2019s lives and contribute to society.\u201d<\/p>\n<p class=\"css-at9mc1 evys1bk0\">After studying agriculture at Tohoku University, he joined Sankyo, a Japanese pharmaceutical company, in the late 1950s. His first assignment was manufacturing enzymes for fruit juices and wines at a factory in Tokyo.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">He developed a more efficient way of cultivating mold by applying a method he had used as a child to make miso and pickled vegetables, he later told M3, a website for Japanese medical professionals. His reward was a promotion to the company\u2019s microbiology and chemistry laboratory.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">In the 1960s, he received a doctoral degree in biochemistry from Tohoku University. He also lived for a few years in New York City, where he worked as a research associate at Albert Einstein College of Medicine.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">At the time, he later told M3, he wanted to invent a cure for stroke, the leading cause of death in Japan. Strokes had caused the deaths of his father and his grandparents.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div>\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">\u201cBut when I went to the States, I learned there were many heart disease cases, so I switched,\u201d he said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Back at Sankyo, he grew more than 6,000 fungi in the early 1970s as part of an effort to find a natural substance that could block a crucial enzyme involved in the production of cholesterol.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cI knew nothing but mold, so I decided to look for it in mold,\u201d he said.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">He eventually found what he was looking for: a strain of <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2019\/10\/15\/science\/cheese-fungus-mold-camembert.html\" title=\"\">penicillium<\/a>, or blue mold, that, in chickens, reduced levels of an enzyme that cells need to make LDL cholesterol.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">Dr. Endo\u2019s survivors include his wife, Orie, his son, Osamu, and his daughter, Chiga, according to Endo Akira Kenshokai. Complete information on survivors was not immediately available.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">After Dr. Endo left Sankyo in the late 1970s, he worked as a professor at several Japanese universities and served as the president of Biopharm Research Laboratories, a Japanese pharmaceutical company. In 2008, he <a class=\"css-yywogo\" href=\"https:\/\/www.nytimes.com\/2008\/09\/14\/health\/14lasker.html\" title=\"\">received a Lasker Award<\/a>, a prestigious honor from a foundation in New York, for his medical research.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<div>\n<div class=\"css-53u6y8\">\n<p class=\"css-at9mc1 evys1bk0\">Dr. Endo said in the 2014 interview that he had tried to build a career around solving a global problem that was not particular to Japan. He likened his work to scaling peaks much taller than Mount Takao in Tokyo.<\/p>\n<p class=\"css-at9mc1 evys1bk0\">\u201cIf I were to climb a mountain,\u201d he said, \u201cMount Everest would be better.\u201d<\/p>\n<p class=\"css-798hid etfikam0\">Orlando Mayorqu\u00edn<!-- --> contributed reporting.<\/p>\n<\/div>\n<aside class=\"css-ew4tgv\" aria-label=\"companion column\"\/><\/div>\n<p><br \/>\n<br \/><a href=\"https:\/\/www.nytimes.com\/2024\/06\/12\/world\/asia\/akira-endo-dead.html\">Source link <\/a><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Akira Endo, a Japanese biochemist whose research on fungi helped to lay the groundwork for widely prescribed drugs that lower a type of cholesterol that contributes to heart disease, died on June 5. He was 90. Chiba Kazuhiro, the president of Tokyo University of Agriculture and Technology, where Dr. Endo was a professor emeritus, confirmed [&hellip;]<\/p>\n","protected":false},"author":2,"featured_media":71639,"comment_status":"open","ping_status":"open","sticky":false,"template":"","format":"standard","meta":{"tdm_status":"","tdm_grid_status":"","fifu_image_url":"https:\/\/static01.nyt.com\/images\/2024\/06\/12\/multimedia\/12XP-ENDO-gztp\/12XP-ENDO-gztp-facebookJumbo.jpg","fifu_image_alt":"","footnotes":""},"categories":[1],"tags":[66134,16,8069,66135,2462,10163,66136,66137],"amp_enabled":true,"_links":{"self":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/71638"}],"collection":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts"}],"about":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/types\/post"}],"author":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/users\/2"}],"replies":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/comments?post=71638"}],"version-history":[{"count":1,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/71638\/revisions"}],"predecessor-version":[{"id":71640,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/posts\/71638\/revisions\/71640"}],"wp:featuredmedia":[{"embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media\/71639"}],"wp:attachment":[{"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/media?parent=71638"}],"wp:term":[{"taxonomy":"category","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/categories?post=71638"},{"taxonomy":"post_tag","embeddable":true,"href":"https:\/\/news.talkwithrattan.com\/index.php\/wp-json\/wp\/v2\/tags?post=71638"}],"curies":[{"name":"wp","href":"https:\/\/api.w.org\/{rel}","templated":true}]}}